LiverPool™ Cryoplateable Human Hepatocytes
Hepatocytes from BioreclamationIVT are cryopreserved the same day they are isolated, and come with full serology reporting for your safety. LiverPool cryoplateable human hepatocytes are used for long term studies (≥4 hours) like induction, toxicity, and transport. More recently, scientists also have been using cryoplateable hepatocytes to study transporter uptake, viral transduction and gene induction.
BioreclamationIVT's LiverPool cryoplateable human hepatocytes have high levels of induction following treatment with known inducers omeprazole (CYP1A2), phenobarbital (CYP2B6), and rifampin (CYP3A4). All plateable lots have greater than 70% viability and greater than 70% confluence on day 5. Cells are also treated with CDFDA fluorescent dye to show bile caniculi formation.
The process for producing the LiverPool™ pooled human hepatocyte products is covered by one or more U.S. or foreign patents and patent applications, including U.S. Patent No. 7,604,929.